Pramipexole-induced limb dystonia and its associated complex regional pain syndrome in idiopathic Parkinson's disease
نویسنده
چکیده
RATIONALE This case may be due to basal ganglia dysfunction, which was probably caused by abnormal activation of dopamine 1-like receptor (D1R) boosted by pramipexole binding on dopamine 3-like receptor (D3R) in a situation where D3R was overexpressed by the chronic treatment of L-dopa. PATIENT CONCERNS Striatal hand and foot deformities. DIAGNOSES Striatal hand and foot deformities with CRPS. INTERVENTIONS Steroid treatemnt and withdrawal of the pramipexole. OUTCOMES Recovered significantly. LESSONS Since the degree of overexpression of D3R is increased in a high dose of pramipexole, for patients with PD who are treated with L-dopa chronically, a new use of pramipexole and an increase in dose to alleviate the symptoms of PD should be implemented with caution while closely observing the occurrence of drug-induced complications such as dystonia and CRPS.
منابع مشابه
Complex regional pain syndrome with dystonia in childhood
Background We present 6 children with Complex regional pain syndrome (CRPS) in whom dystonia, including abnormal posture and involuntary movement was a prominent feature. CRPS is known to occur in childhood usually involving severe limb pain, colour and temperature change, with associated loss of function. Dystonia associated with CRPS has never been described in children, although a few cases ...
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